| Product Name | Na+ CP type IIIβ Antibody (G-21) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of Na+ CP type IIIβ of mouse, rat and human origin by WB, IP and ELISA |
| Modification Notes | Voltage-gated Na+ channels regulate the permeability of excitable cells to sodium ions. During the propagation of an action potential, Na+ channels allow an influx of sodium ions, which rapidly depolarize the cell. The sodium channel protein is comprised of one å subunit and two ∫ subunits. The Na+ CP type I and Na+ CP type IIå subunits are expressed in adult brain. Na+ CP type IIIå is expressed in embryonic brain, but not in adult brain. Na+ CP type III∫ is a 215 amino acid, single-pass type I membrane protein that modulates sodium channel gating kinetics and inactivates the channel opening more slowly than the I∫ subunit. It has an extracellular N-terminal domain, an N-terminal signal sequence, a single membrane-spanning region and a C-terminal cytoplasmic region. Expression of Na+ CP type III∫ is upregulated in response to DNA damage. In association with Neurofascin, Na+ CP type III∫ may target the sodium channels to nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of Na+ CP type III&beta of mouse rat and human origin by WB IP and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of Na+ CP type IIIβ of mouse, rat and human origin by WB, IP and ELISA |
| Entrez Gene | 55800 |
|---|
| Application Notes | WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
