| Product Name | Nkx-6.3 Antibody (O-25) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of Nkx-6.3 of human origin by WB, IP and ELISA |
| Modification Notes | Members of the Nkx family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas. The Nkx-6 family is involved in the patterning of the pancreas and central nervous system and consists of three proteins: Nkx-6.1, Nkx-6.2 and Nkx-6.3. Nkx-6.1 is responsible for cellular differentiation in the ventral neural tube and spinal meninges in response to Shh. Nkx-6.2 is also expressed during neural tube development by neural progenitor cells. During development, Nkx-6.2 regulates interneuron fates by repressing the expression of Dbx1, a class I homeodomain transcription repressor. Nkx-6.3 is a 265 amino acid homeobox protein that shows selective expression in the duodenal and glandular endoderm, in contrast to Nkx-6.1 and Nkx-6.2 that are broadly expressed in the ventral positions of the developing CNS. Nkx-6.3 is required in differentiation of gastrin-producing G-cells in the stomach and antrum. There are two isoforms of Nkx-6.3 that are produced as a result of alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of Nkx-6.3 of human origin by WB IP and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of Nkx-6.3 of human origin by WB, IP and ELISA |
| Entrez Gene | 157848 |
|---|
| Application Notes | WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
