| Modification Notes |
The snail family of developmental regulatory proteins is a group of widely conserved zinc-finger transcription factors that are involved in morphogenesis, cell division and cell survival. Scratch2, also known as SCRT2, is a 307 amino acid protein that contains five C2H2-type zinc fingers and belongs to the snail C2H2-type zinc-finger protein family. Localized to the nucleus, Scratch2 is thought to be involved in transcriptional regulation events, specifically functioning in the inner part of the cerebellar external granular layer, as well as in the postnatal cortical subventricular zone and in the glial cells of the adult vomeronasal nerve. The gene encoding Scratch2 maps to human chromosome 20, which houses over 600 genes and comprises nearly 2% of the human genome. |