| Modification Notes |
ATP11A (ATPase, class VI, type 11A), also known as ATPIS or ATPIH, is a 1,134 amino acid multi-pass membrane protein that belongs to the cation transport ATPase family and is expressed in a variety of tissues, including testis, brain, spleen and pancreas.. Existing as two alternatively spliced isoforms, ATP11A uses ATP to drive the transport of ions, such as calcium, across cellular membranes. Human ATP11A shares 91% sequence identity with its mouse counterpart, suggesting a conserved role between species. The gene encoding ATP11A maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. |