| Product Name | COMMD5 Antibody (FL-224) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-224 representing full length COMMD5 of human origin |
| Modification Notes | COMMD family members are a group of evolutionary conserved proteins that share a common COMM domain at the extreme C-terminus, which provides an interface for protein-protein interactions. Most, if not all, COMMD proteins have been found to play a role in the regulation NF˚B and, despite their similarities, seem to function in unique and non-redundant pathways. COMMD proteins may also play a role in the function of epithelial sodium channels, cell proliferation, copper homeostasis and in the regulation of the ubiquitin pathway. As a member of the COMMD family, COMMD5 (COMM domain-containing protein 5), also known as HCaRG (hypertension-related calcium-regulated gene protein), is a 224 amino acid protein that is negatively regulated by extracellular calcium concentrations. Due to lower proliferation rates observed in COMMD5-transfected HEK293 cells, it is suggested that COMMD5 may play a regulatory role in cell proliferation. COMMD5 is localized to the nucleus and is expressed in stomach, liver, kidney, heart, adrenal gland and jejunum, with higher levels of mRNA expression found in hypertensive animals. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of COMMD5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-224 representing full length COMMD5 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-224 representing full length COMMD5 of human origin |
| Entrez Gene | 28991 |
|---|
| Application Notes | recommended for detection of COMMD5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
