Application
Western blot analysis of TBC1D1 expression in Ramos (A), BJAB (B) and Daudi (C) whole cell lysates.| Product Name | TBC1D1 Antibody (C-22) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of TBC1D1 of human origin by WB and IP |
| Modification Notes | GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. TBC1D1 (TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1), also known as TBC1 or TBC, is a 1,168 amino acid protein that belongs to a family of proteins which share a ~200 amino acid TBC domain that may convey a role in the regulation of cell growth and differentiation. Localized to the nucleus and containing one PID domain and one Rab-GAP TBC domain, TBC1D1 is thought to function as a GTPase-activating protein for Rab proteins, possibly participating in Rab-mediated cell cycle control and, ultimately, cellular differentiation. TBC1D1 is highly expressed in ovary, kidney and testis and is encoded by a gene which maps to human chromosome 4 and may be associated with an increased susceptibility to severe obesity. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIP |
| WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of TBC1D1 of human origin by WB and IP |
|---|---|
| Tissue Specificity | recommended for detection of TBC1D1 of human origin by WB and IP |
| Entrez Gene | 23216 |
|---|
Application
Western blot analysis of TBC1D1 expression in Ramos (A), BJAB (B) and Daudi (C) whole cell lysates.| Application Notes | WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
