Application
Western blot analysis of PBF expression in non-transfected: (A) and human PBF transfected: (B) 293T whole cell lysates.| Product Name | PBF Antibody (C-19) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the C-terminus of PBF of human origin |
| Modification Notes | PBF, also known as PTTG1IP (pituitary tumor-transforming 1 interacting protein), is a 180 amino acid single-pass type I membrane protein that localizes to both the cytoplasm and the nucleus and contains a coiled-coil domain. Expressed ubiquitously, PBF interacts with PTTG and is thought to facilitate the nuclear translocation of PTTG, thereby allowing the PTTG-dependent transcriptional activation of fibroblast growth factor (FGF). The gene encoding PBF maps to human chromosome 21, which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer's Disease, amyotrophic lateral sclerosis and, most notably, Down Syndrome (also known as trisomy 21). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PBF of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with PTTG or PTTG1: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the C-terminus of PBF of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the C-terminus of PBF of human origin |
| Entrez Gene | 754 |
|---|
Application
Western blot analysis of PBF expression in non-transfected: (A) and human PBF transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of PBF of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with PTTG or PTTG1: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
