| Product Name | PDIR Antibody (H-120) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 184-303 mapping within an internal region of PDIR of human origin |
| Modification Notes | Oxidoreductase-protein disulfide isomerase (PDI) is a homodimer that catalyzes thiol-disulfide exchange, mediates folding of newly synthesized proteins and functions as a molecular chaperone. PDIR (Protein disulfide isomerase-related protein), also known as PDIA5 (Protein disulfide-isomerase A5), is a 519 amino acid protein that catalyzes the rearrangement of sulfur-sulfur bonds in various proteins. Localized to the lumen of the endoplasmic reticulum (ER), PDIR has an oxidative refolding activity that is specific for å1-antitrypsin (AAT) and aids in the formation of disulfide bonds in the ER lumen. PDIR contains one ER retention signal at its C-terminus and three thioredoxin (CXXC) motifs which mediate the substrate-specific isomerase, chaperone and redox activity of PDIR. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PDIR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 184-303 mapping within an internal region of PDIR of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 184-303 mapping within an internal region of PDIR of human origin |
| Entrez Gene | 10954 |
|---|
| Application Notes | recommended for detection of PDIR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
