Application
Western blot analysis of HoxA10 expression in non-transfected: (A) and mouse HoxA10 transfected: (B) 293T whole cell lysates.| Product Name | HoxA10 Antibody (H-90) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 221-310 mapping within an internal region of HoxA10 of human origin |
| Modification Notes | The Hox homeobox genes encode proteins that are transcriptional regulators with an established role in embryonic development. The HoxA10 gene is related to the Abdominal B (AbdB) homeobox subfamily of genes and is expressed in both the developing genitourinary tract and in the adult uterus. HoxA10 expression increases during the midsecretory phase of the menstrual cycle, which corresponds with increased levels of circulating progesterone, as evidenced by Northern blot analysis. Furthermore, HoxA10 expression in-creases in a concentration-dependent manner with progesterone stimulation in cultured endometrial cells and is blocked by the progesterone receptor antagonist RU486. In addition, HoxA10 is differentially expressed in the myometrium throughout the menstrual cycle, both in vivo and in vitro, with decreased expression coinciding with increased progesterone levels. In contrast with a control group, female patients with documented endometriosis do not exhibit a mid-luteal increase in uterine Hox gene expression, which may contribute to the pathology of the disease. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISAChIP |
| recommended for detection of HoxA10 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 221-310 mapping within an internal region of HoxA10 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 221-310 mapping within an internal region of HoxA10 of human origin |
| Entrez Gene | 3206 |
|---|
Application
Western blot analysis of HoxA10 expression in non-transfected: (A) and mouse HoxA10 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of HoxA10 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
