Drosophila melanogaster is a proven and effective model for studying developmental and cellular processes common to higher eukaryotes. Approximately 13,600 genes have been elucidated from more than 120 megabases of euchromatin, and they are organized among the chromosomes 2, 3, 4, X and Y, with the Y chromosome being predominately heterochromatic. The male-specific lethal (MSL) genes (including MSL3L1 and MSL3L2) are essential for X-chromosome dosage compensation. The human gene MSL3L1 encodes a protein with significant homology to Drosophila MSL-3 in three distinct regions, which include two putative chromo domains. The MSL3L1 gene maps to a chromosomal location implicated in several disorders, including microphthalmia with linear skin defects (MLS or MIDAS), OFD1 and SED tarda, as well as Aicardi syndrome and Goltz syndrome.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of MSL3L1 of mouse, rat, human and canine origin by WB, IP and ELISA: