Application
Western blot analysis of ZNF365 expression in Hep G2 whole cell lysate.| Product Name | ZNF365 Antibody (O-25) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against ZNF365 of human origin |
| Modification Notes | Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF365 (zinc finger protein 365) is a 407 amino acid protein with its expression restricted to brain, lung, liver, placenta, kidney and pancreas. Overexpression of ZNF365 causes abnormal mitosis and mutant ZNF365 lacking a C-terminus disrupts ©-tubulin localization to the nucleus. Alternative splicing results in at least four different isoforms of ZNF365, designated ZNF365A-D. A mutation in the gene encoding ZNF365 disrupts the expression of ZNF365D (also known as Talanin) and is involved in susceptibilty to uric acid nephrolithiasis, a multifactorial urinary tract stone disease that is influenced by genetics and environmental factors. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| recommended for detection of ZNF365 of mouse, rat and human origin by WB, IP and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against ZNF365 of human origin |
|---|---|
| Tissue Specificity | raised against ZNF365 of human origin |
| Entrez Gene | 22891 |
|---|
Application
Western blot analysis of ZNF365 expression in Hep G2 whole cell lysate.| Application Notes | recommended for detection of ZNF365 of mouse, rat and human origin by WB, IP and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
