Application
Western blot analysis of RIN3 expression in Hep G2 whole cell lysate.| Product Name | RIN3 Antibody (B-17) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against RIN3 of human origin |
| Modification Notes | The Ras oncogene family, whose members include Rab 5B and Rab 5C, encode membrane-associated small G proteins that are regulated, in part, by the activity of guanine nucleotide exchange factors (GEFs). The RIN family of Ras interaction-interference proteins (namely RIN1, RIN2, RIN3 and RIN4) comprise a group of Rab 5 binding partners that interact with and control Rab 5 function. RIN3 (Ras and Rab interactor 3) is a 984 amino acid member of the RIN family and is thought to associate with Rab 5B and function as a GEF, exchanging bound GDP for free GTP. Expressed throughout the body, RIN3 is a cytoplasmic protein that contains one VPS9 domain, one SH2 domain and one Ras-associating domain. In addition to its probable role as a Rab 5B-associated GEF, RIN3 is thought to participate in intracellular transport between the plasma membrane and early endosomes. Four isoforms of RIN3 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| recommended for detection of RIN3 of human origin by WB, IP and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against RIN3 of human origin |
|---|---|
| Tissue Specificity | raised against RIN3 of human origin |
| Entrez Gene | 79890 |
|---|
Application
Western blot analysis of RIN3 expression in Hep G2 whole cell lysate.| Application Notes | recommended for detection of RIN3 of human origin by WB, IP and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
