| Modification Notes |
ENY2 (Enhancer of yellow 2 transcription factor homolog) is a 101 amino acid nuclear protein that is a component of the acetylation complex SAGA and belongs to the ENY2 family. The SAGA complex is composed of several proteins, which together activate transcription by remodeling chromatin and regulating histone deubiquitination and acetylation. As a component of the SAGA complex, ENY2 is involved in a subcomplex that deubiquitinates histones H2A and H2B. The entire SAGA complex is directed to specific gene promoters where it is required for transcription. ENY2 is required for nuclear receptor-mediated transactivation. In addition, ENY2 may also be involved in mRNA export as well as accurate chromatin positioning in the nucleous. ENY2 is thought to tether genes into the nuclear periphery. The gene encoding ENY2 maps to human chromosome 8. |