| Product Name | SART-1 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 107-406 mapping near the N-terminus of SART-1 of human origin |
| Modification Notes | SART-1 (squamous cell carcinoma antigen recognized by T cells), also known as Ara1, HOMS1 or Snu66, is a ubiquitously expressed protein that is involved in mRNA splicing and cell proliferation. The gene encoding SART-1 is posttranscriptionally modified to produce two proteins: SART-1(800), which is the native transcript and is localized to the nucleus of proliferating cells, and SART-1(259), which is expressed in the cytosol of epithelial cancers. While both proteins are involved in regulating cell proliferation, SART-1(259) is also an essential component in the spliceosome C assembly pathway playing a role in pre-mRNA splicing. SART-1(259) possesses a tumor-rejection antigen that can induce restricted cytotoxic T lymphocytes in cancer patients, suggesting a possible role in immunotherapy. Additionally, the polymorphic variation within the SART-1 gene may be a cause of atopy, an allergic hypersensitivity characterized by eczema, asthma and allergic conjunctivitis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SART-1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 107-406 mapping near the N-terminus of SART-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 107-406 mapping near the N-terminus of SART-1 of human origin |
| Entrez Gene | 9092 |
|---|
| Application Notes | recommended for detection of SART-1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
