| Product Name | LTBP-2 Antibody (H-270) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 211-480 mapping within an internal region of LTBP-2 of human origin |
| Modification Notes | Transforming growth factor (TGF) b is secreted as a part of an inactive complex that frequently contains latent TGF∫-binding protein (LTBP) (1). The LTBP family of proteins exhibit a multidomain structure containing cysteine-rich motifs (1). LTBP-2 is an integral component of elastin-containing microfibrils (1-3) and contains 20 EGF-like repeats and four copies of an 8-cysteine repeat (4). LTBP-2 is synthesized as a protein by human foreskin fibroblasts (4). LTBP-2 co-localizes with tropoelastin in several tissues, including lung, dermis, epicardium, pericardium and heart valves, throughout rodent development, and in the spleen in the young adult mouse (2). Pseudoexfoliation (PEX) syndrome is a systemic condition characterized by the pathologic production and accumulation of an abnormal fibrillar extracellular material in many intra- and extraocular tissues (5). The co-localization of LTBP-1 and LTBP-2 with latent TGF∫1 and with fibrillin-1 on PEX fibrils suggests a possible mechanism for the regulation of TGF∫1 activity in PEX eyes (5). The LTBP-2 gene maps to human chromosome 14q24 (4). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of LTBP-2 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 211-480 mapping within an internal region of LTBP-2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 211-480 mapping within an internal region of LTBP-2 of human origin |
| Entrez Gene | 4053 |
|---|
| Application Notes | recommended for detection of LTBP-2 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
