Application
Western blot analysis of BANK1 expression in mouse lymph node tissue extract (A), HeLa (B) and PC-3 (C) whole cell lysates.| Product Name | BANK1 Antibody (S-12) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the C-terminus of BANK1 of human origin |
| Modification Notes | BANK1 (B-cell scaffold protein with ankyrin repeats) is a 785 amino acid protein that contains one DBB domain and two ANK (ankyrin) repeats. Expressed in a variety of B-cells with particularly high expression in CD19(+) B-cells, BANK1 interacts with Lyn, IP3R-I and IP3R-II and is involved in B-cell receptor-induced calcium mobilization from intracellular calcium stores. Via its association with Lyn, BANK1 promotes Lyn-mediated tyrosine phosphorylation of IP3R-I and IP3R-II, an event that activates B-cells and may be required for antigen-induced immune responses within the body. Defects in the gene encoding BANK1 increase the genetic susceptibility to systemic lupus erythematosus (SLE), a chronic inflammatory disorder that affects joints, skin, serosal membranes and kidney tissue. BANK1 exists as four isoforms that are produced by alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of BANK1 isoforms 1-4 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the C-terminus of BANK1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the C-terminus of BANK1 of human origin |
| Entrez Gene | 55024 |
|---|
Application
Western blot analysis of BANK1 expression in mouse lymph node tissue extract (A), HeLa (B) and PC-3 (C) whole cell lysates.| Application Notes | recommended for detection of BANK1 isoforms 1-4 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
