| Product Name | BIGM103 Antibody (P-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an extracellular domain of BIGM103 of human origin |
| Modification Notes | BIGM103 (BCG-induced integral membrane protein in monocyte clone 103 protein), also known as Zinc transporter ZIP8 or solute carrier family 39 member 8, is a 460 amino acid protein belonging to the ZIP transporter family. While other members of the protein family are constitutively expressed, BIGM103 is induced by inflammatory cytokines, such as TNFå. Upon induction, BIGM103 translocates to the plasma membrane and mitochondria, where it functions in the cellular import of zinc. As zinc is an essential cytoprotectant involved in the host response to inflammatory stress, BIGM103, too, functions as a cytoprotectant and plays a critical role in cell survival. Additionally, BIGM103 is thought to be the primary transporter of cadmium. BIGM103 is expressed in thymus, placenta, lung and liver, with highest levels in pancreas. Two isoforms of BIGM103 exist as a result of alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of BIGM103 isoforms 1 and 2 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an extracellular domain of BIGM103 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an extracellular domain of BIGM103 of human origin |
| Entrez Gene | 64116 |
|---|
| Application Notes | recommended for detection of BIGM103 isoforms 1 and 2 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
