The removal of introns from a transcribed pre-mRNA segment is facilitated by a complex known as the spliceosome. Spliceosome assembly is initiated by the binding of U1 small nuclear ribonucleoprotein particle (U1 SnRNP) to the 5’ splice site and the U2 SnRNP auxiliary factor (U2AF) to the pyrimidine tract. ZRSR2, also known as U2 small nuclear ribonucleoprotein auxiliary factor 35kDa subunit-related protein 2 (U2AF1RS2), U2AF01RS2 or U2AF1L2, is a 482 amino acid protein that is related to U2AF35. ZRSR2 has been shown to interact with U2AF65 and SR proteins in the splicing of pre-mRNA. Localized to the nucleus, ZRSR2 contains two C3H1-type zinc fingers and one RNA recognition motif (RRM) domain, a 90 amino acid region that is responsible for RNA-binding.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFIHCELISA
recommended for detection of ZRSR2 of human origin by WB, IP, IF, IHC(P) and ELISA: