Application
LYNX1 Antibody (Center) (Cat. #AP17173c) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the LYNX1 antibody detected the LYNX1 protein (arrow).| Product Name | LYNX1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LYNX1; Ly-6/neurotoxin-like protein 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | SLURP2 |
|---|---|
| Alternative Names | LYNX1 Ly-6/neurotoxin-like protein 1 |
| Molecular Weight(MW) | 14026 Da |
| Function | Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain, isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and slowing recovery from desensitization Promotes large amplitude ACh-evoked currents through alpha(4)beta(2) nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (By similarity). In keratinocytes, isoform 3 delays differentiation and prevents apoptosis |
| Tissue Specificity | Isoform 3 is expressed at highest levels in cervix and esophagus, followed by adult and fetal skin. Expressed at lower levels in brain, lung, stomach, small intestine, colon, rectum, uterus, and thymus. Not detected in spleen nor bone marrow. In the epidermis, predominantly produced by keratinocytes of the suprabasal epidermal compartment (at protein level). In attached gingiva, produced at highest levels by basal cells located in the lowermost epithelial layers (at protein level). Up- regulated 3-fold in psoriatic lesional skin. Detected in serum (at protein level) |
| Cellular Localization | Isoform 1: Secreted (Potential). Isoform 3: Secreted. |
| Entrez Gene | 66004 |
|---|---|
| Nucleotide Accession | NP_803252.1 NP_803429.1 |
Application
LYNX1 Antibody (Center) (Cat. #AP17173c) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the LYNX1 antibody detected the LYNX1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
