| Product Name | p-tuberin Antibody (Thr 1462) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to phosphorylated Thr 1462 of tuberin of human origin |
| Modification | Phosphoralated |
| Modification Notes | Hamartin (TSC1) and tuberin (TSC2, LAM, TSC4) can form a functional complex and negatively regulate cell growth by inhibiting protein synthesis. Tuberous sclerosis complex (TSC) is a genetic disorder that arises through mutations in the hamartin and tuberin genes. The phosphoinositide 3-kinase (PI3K)/Akt pathway phosphorylates tuberin on serine-939 and threonine-1462 and inhibits the tumor suppressor function of the TSC complex. Anisomycin stimulates phosphorylation of serine-1210 of tuberin via the p38-MK2 kinase cascade. Phosphorylation of tuberin by MK2 creates a 14-3-3 binding site. Phosphorylation of hamartin regulates the function of the hamartin-tuberin complex during the G2/M phase of the cell cycle. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Thr 1462 phosphorylated tuberin of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to phosphorylated Thr 1462 of tuberin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to phosphorylated Thr 1462 of tuberin of human origin |
| Entrez Gene | 7249 |
|---|
| Application Notes | recommended for detection of Thr 1462 phosphorylated tuberin of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
