| Product Name | MEL-1A/B-R Antibody (H-120) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 161-280 mapping within an internal region of MEL-1A-R of human origin |
| Modification Notes | Melatonin (Mel), a hormone secreted by the pineal gland, is expressed at night in response to the circadian clock (1,2). Melatonin is thought to be involved in regulating reproductive physiological development and the progression of sexual maturation, and it is also thought to play a role in tumorigenesis (1,3). The melatonin receptors, MEL-1A-R and MEL-1B-R, are members of the super-family of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors (4,5). Signaling through the melatonin receptors inhibits adenylate cyclase and stimulates phospholipase Cb upon activation of pertussis toxin (PTX)-sensitive G proteins (4,5). MEL-1A-R may be involved in pacing the biological clock (5). However, both MEL-1A-R and MEL-1B-R are implicated in controlling cellular growth in response to melatonin (6,7). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MEL-1A-R and MEL-1B-R of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 161-280 mapping within an internal region of MEL-1A-R of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 161-280 mapping within an internal region of MEL-1A-R of human origin |
| Entrez Gene | 4543 |
|---|
| Application Notes | recommended for detection of MEL-1A-R and MEL-1B-R of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
