| Product Name | OSMR β Antibody (M-190) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 782-971 mapping at the C-terminus of OSMR β of mouse origin |
| Modification Notes | Oncostatin M (OSM) is a glycoprotein that inhibits the growth of a broad range of human tumor cell lines, but does not influence the growth of normal human fibroblasts. Expression of OSM is greatest in activated monocytic and lymphocytic cell lines and in normal adherent macrophages. Amino acid sequence analysis of OSM has revealed homology with leukemia inhibitory factor (LIF), granulocyte colony stimulating factor (G-CSF) and interleukin 6 (IL-6), all of which affect the growth and differentiation of a broad range of cell types, including those of hematopoietic origin. OSMR ∫ (oncostatin M receptor ∫), also known as OSMR, is a 979 amino acid single-pass type I membrane protein that functions as a receptor for OSM. Expressed at high levels in neural cells, as well as fibroblast and epithelial tumor lines, OSMR ∫ exists as a heterodimer that interacts with interleukins and is able to transduce OSM-induced signaling events. Defects in the gene encoding OSMR ∫ are the cause of primary cutaneous amyloidosis (PCA), an autosomal dominant disorder characterized by chronic itching of the skin. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of OSMR β of mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 782-971 mapping at the C-terminus of OSMR &beta of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 782-971 mapping at the C-terminus of OSMR β of mouse origin |
| Entrez Gene | 18414 |
|---|
| Application Notes | recommended for detection of OSMR β of mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
