| Product Name | HoxB1 Antibody (H-170) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 11-180 mapping near the N-terminus of HoxB1 of human origin |
| Modification Notes | HOX genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. The homeobox gene Hoxb-1 is critical to hindbrain development and has phenotypic features frequently observed in autism. Analysis of expression and targeted disruption of Hoxb-1 demonstrates that it is also essential for patterning progenitor cells along the entire DV axis of rhombomere 4 (r4). Hoxb-1 maintains this function by acting very early during hindbrain neurogenesis to specify effectors of the sonic hedgehog and Mash1 signaling pathways. Hoxb2 is a homeodomain protein important in neural development that is also expressed during erythropoiesis, hindbrain development and normal human adult lung development. Hoxb2 may modulate the amount of gamma-globin mRNA expressed during development and differentiation. In addition, Hoxb2 plays an important role in the patterning of hindbrain and pharyngeal arches in the zebrafish. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISAGSChIP |
| recommended for detection of HoxB1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 11-180 mapping near the N-terminus of HoxB1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 11-180 mapping near the N-terminus of HoxB1 of human origin |
| Entrez Gene | 3211 |
|---|
| Application Notes | recommended for detection of HoxB1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
