Application
Western blot analysis of HoxB6 expression in non-transfected 293T: (A) and mouse HoxB6 transfected 293T: (B) 293T whole cell lysates.| Product Name | HoxB6 Antibody (H-100) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 21-120 mapping near the N-terminus of HoxB6 of human origin |
| Modification Notes | HOX genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. There are multiple transcripts of the HoxB3 gene, and the anterior boundaries of its expression vary at different stages of development. HoxB3 plays a role in the proliferation and differentiation of both early myeloid and lymphoid developmental pathways. HoxB3 also has overlapping function in mediating the migration of pharyngeal organ primordia and is expressed in very restricted domains in the future hindbrain. HoxB6 controls the generation, proliferation and survival of erythroid progenitor cells. The HoxB6 protein is expressed in the suprabasal layer of the early developing epidermis and throughout the upper layers of late fetal and adult human skin. HoxB6 is cytoplasmically expressed throughout fetal epidermal development, but displays nuclear expression in normal adult skin. HoxB6 protein also has nuclear expression in hyperproliferative skin conditions, but appears to be localized in the cytoplasm in basal and squamous cell carcinomas. HoxB6 genes are also expressed in normal adult lung. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISAGSChIP |
| recommended for detection of HoxB6 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 21-120 mapping near the N-terminus of HoxB6 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 21-120 mapping near the N-terminus of HoxB6 of human origin |
| Entrez Gene | 3216 |
|---|
Application
Western blot analysis of HoxB6 expression in non-transfected 293T: (A) and mouse HoxB6 transfected 293T: (B) 293T whole cell lysates.| Application Notes | recommended for detection of HoxB6 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
