| Modification Notes |
TCEB3CL2 (transcription elongation factor B polypeptide 3C-like 2), also known as RNA polymerase II transcription factor SIII subunit A3-like-2 or Elongin-A3-like-2, is a 546 amino acid nuclear protein that contains one TFIIS N-terminal domain. TCEB3CL2 exists as part of a heterotrimer consisting of Elongin-A (A1, A2 or A3), -B and -C subunits. TCEB3CL2 is encoded by a gene mapping to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas. |