Application
Western blot analysis of MTAC2D1 expression in non-transfected 293T: (A), human MTAC2D1 transfected 293T: (B), NIH/3T3 (C) and MCF7 (D) whole cell lysates and NIH/3T3 (E) and MCF7 (F) nuclear extracts.| Product Name | MTAC2D1 Antibody (E-12) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the N-terminus of MTAC2D1 of human origin |
| Modification Notes | MTAC2D1 (membrane targeting tandem C2 domain-containing protein 1), also known as TC2N (tandem C2 domains nuclear protein), C2CD1 or Tac2-N, is a 490 amino acid protein that localizes to the nucleus and contains one C2 domain. Existing as two alternatively spliced isoforms, MTAC2D1 is encoded by a gene that maps to human chromosome 14q32.12 and mouse chromosome 12 E. Chromosome 14 houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder å1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MTAC2D1 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of MTAC2D1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of MTAC2D1 of human origin |
| Entrez Gene | 123036 |
|---|
Application
Western blot analysis of MTAC2D1 expression in non-transfected 293T: (A), human MTAC2D1 transfected 293T: (B), NIH/3T3 (C) and MCF7 (D) whole cell lysates and NIH/3T3 (E) and MCF7 (F) nuclear extracts.| Application Notes | recommended for detection of MTAC2D1 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
