| Product Name | Nop10 Antibody (H-54) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 11-64 mapping at the C-terminus of Nop10 of human origin |
| Modification Notes | Nop10, also known as NOLA3 (nucleolar protein family A member 3), is a 64 amino acid protein that localizes to the nucleolus, as well as to cajal bodies, and exists as a component of the multi-protein H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex. Working in tandem with other members of the H/ACA snoRNP complex, Nop10 plays an essential role in telomere maintenance and ribosome biogenesis and is also thought to be required for the proper processing and trafficking of the TERT (telomerase reverse transcriptase) holoenzyme. Defects in the gene encoding Nop10 are the cause of dyskeratosis congenita autosomal recessive (ARDKC), a rare and progressive bone marrow failure syndrome that is characterized by reticulated skin hyperpigmentation, nail dystrophy and mucosal leukoplakia. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Nop10 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 11-64 mapping at the C-terminus of Nop10 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 11-64 mapping at the C-terminus of Nop10 of human origin |
| Entrez Gene | 55505 |
|---|
| Application Notes | recommended for detection of Nop10 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
