| Modification Notes |
VCC-1 (VEGF co-regulated chemokine 1), also known as Dcip1, DMC (dendritic cell and monocyte chemokine-like protein) or CXCL17 (C-X-C motif chemokine 17), is a 119 amino acid secreted protein that plays a role in angiogenesis. A member of the intercrine alpha (chemokine CxC) family, VCC-1 is expressed in skeletal muscle, trachea, lung, intestine and stomach, and is upregulated in duodenal mucosa of patients with acute cholera, as well as breast tumors. VCC-1 is considered a housekeeping chemokine for the movement of immature dendritic cells and non activated blood monocytes into tissues, and is though to be involved in the innate immune response. The gene encoding VCC-1 maps to human chromosome 19q13.2 and mouse chromosome 7 A3. |