Application
Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.Application
Western blot analysis of Presenilin 1 expression in non-transfected: (A) and mouse Presenilin 1 transfected: (B) 293T whole cell lysates.Application
Western blot analysis of human recombinant Presenilin 1 fusion protein.| Product Name | Presenilin 1 Antibody (H-70) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-70 mapping at the N-terminus of Presenilin 1 of human origin |
| Modification Notes | A novel protein, designated Presenilin 1 (also designated S182) and mapping to the AD3 locus of chromosome 14q24.2, has been described. Mutations in PSEN1, the gene encoding Presenilin 1, have been found in families suffering from early-onset Alzheimer’s disease. A highly related protein, designated Presenilin 2 (also designated STM2), shares 80% amino acid sequence identity with Presenilin 1. Presenilin 1 and 2 have similar structures and represent novel members of the seven-pass transmembrane receptor superfamily. Point mutations in the gene encoding Presenilin 2 have been found in Volga German families who suffer from an inherited form of early-onset Alzheimer’s disease. Whether these proteins function as ligand-gated ion channels or G protein-coupled receptors has yet to be resolved. ALG-3, the mouse homolog of human Presenilin 2, has been cloned from the mouse liver cDNA library. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Presenilin 1 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-70 mapping at the N-terminus of Presenilin 1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-70 mapping at the N-terminus of Presenilin 1 of human origin |
| Entrez Gene | 5663 |
|---|
Application
Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.
Application
Western blot analysis of Presenilin 1 expression in non-transfected: (A) and mouse Presenilin 1 transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of human recombinant Presenilin 1 fusion protein.| Application Notes | recommended for detection of Presenilin 1 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
