SLC25A25 (solute carrier family 25 member 25), also known as MCSC (mitochondrial calcium-dependent solute carrier protein), PCSCL or SCaMC-2 (small calcium-binding mitochondrial carrier protein 2), is a 469 amino acid multi-pass membrane protein that belongs to the the SLC25 family of mitochondrial carriers that are responsible for transporting metabolites across the inner mitochondrial membrane. Expressed in a wide variety of tissues and localized to the mitochondrion inner membrane, SLC25A25 contains three Solcar repeats and three EF-hand domains and functions as a calcium-dependent mitochondrial solute carrier. More specifically, SLC25A25 acts as an ATP-Mg/Pi co-transporter, facilitating the transport of Mg-ATP in exchange for phosphate. Due to alternative splicing events, six isoforms exist for SLC25A25, namely SCaMC-2a, SCaMC-2b, isoform 3, SCaMC-2c, isoform 5 and SCaMC-2d. SCaMC-2a is ubiquitously expressed while SCaMC-2b expression is limited to lung and kidney.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of SLC25A25 of mouse, rat, human and canine origin by WB, IP and ELISA