Mex-3 (muscle excess protein-3) is a translational regulator in Caenorhabditis elegans that participates in maintaining the germline totipotency and in specification of posterior blastomeres in early embryos. In humans, four evolutionarily conserved Mex-3 homologs exist, namely Mex3a, Mex3b, Mex3c and Mex3d. These proteins comprise a family of RNA binding phosphoproteins which each contain two tandemly repeated KH (nuclear ribonucleoprotein K homology) domains and one C-terminal RING finger motif. In addition, the Mex-3 homolog family of proteins shuttle between the nucleus and the cytoplasm through the CRM1-dependent export pathway and may play a role regulating post-transcriptional events.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of Mex3b of mouse, rat and human origin by WB, IP, IF and ELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 336-385 mapping within an internal region of Mex3b of human origin
Tissue Specificity
epitope corresponding to amino acids 336-385 mapping within an internal region of Mex3b of human origin