| Modification Notes |
RmlB, also known as TGDS (TDP-glucose 4,6-dehydratase), TDPGD or SDR2E1, is a 350 amino acid protein belonging to the dTDP-glucose dehydratase subfamily of the sugar epimerase family. RmIB utilizes NAD as a cofactor and is encoded by a gene located on human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections. |