| Product Name | XRCC4 Antibody (H-233) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA-repair proteins Rad51 and Rad52 are key components of the double-strand-break repair pathway. Rad51 and Rad52 are essential for mitotic and meiotic recombination, and Rad51 mutation in yeast and mammalian cells results in chromosome loss. Rad51 has been shown in separate studies to interact with breast cancer susceptibility gene products BRCA1 and BRCA2, suggesting that these proteins may function as essential cofactors in Rad51-dependent DNA repair. Rad52 has been shown to associate with the RPA complex, a complex involved in DNA replication, nucleotide excision repair and homologous recombination. An additional protein involved in the DSBR pathway has been identified as XRCC4. XRCC4 has been shown to restore DSBR activity as well as V(D)J recombination in cells with impaired DSBR and V(D)J recombination. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of XRCC4 of human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-233 mapping at the N-terminus of XRCC4 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-233 mapping at the N-terminus of XRCC4 of human origin |
| Entrez Gene | 7518 |
|---|
| Application Notes | recommended for detection of XRCC4 of human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
