Application
Western blot analysis of XAB1 expression in Ramos (A), HL-60 (B) and IMR-32 (C) whole cell lysates.| Product Name | XAB1 Antibody (H-248) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | XAB1 (XPA binding protein 1), also known as MBDIN, NTPBP, ATPBD1A or HUSSY-23, is a 374 amino acid cytoplasmic protein that is involved in protein synthesis events. Expressed ubiquitously with highest expression in testis, XAB1 binds to the RNA polymerase II- (Poll II) associated proteins RPAP1-3 and to XPA (a protein involved in DNA repair mechanisms), thereby forming an interface with Poll II. Via this interaction, XAB1 is thought to mediate the involvement of Pol II in both protein complex formation and protein chaperone/scaffolding activities. In addition, XAB1 interacts with components of the integrator and molecular chaperone complexes, further implicating XAB1 in protein assembly. XAB1 contains a cluster of acidic amino acids in its C-terminal region and a series of sequences similar to those found in GTP-binding proteins in its N-terminal region, suggesting that XAB1 has possible GTPase activity. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of XAB1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 127-374 mapping at the C-terminus of XAB1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 127-374 mapping at the C-terminus of XAB1 of human origin |
| Entrez Gene | 11321 |
|---|
Application
Western blot analysis of XAB1 expression in Ramos (A), HL-60 (B) and IMR-32 (C) whole cell lysates.| Application Notes | recommended for detection of XAB1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
