| Product Name | CTDSPL Antibody (N-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The family of small CTD phosphatases preferentially catalyze the dephosphorylation of Ser5 within a concensus repeat. As a member of this family, CTDSPL (CTD small phosphatase-like protein), also known as nuclear LIM interactor-interacting factor 1, RBSP3 or protein YA22, is a 276 amino acid nuclear protein that is ubiquitously expressed. There are two isoforms of CTDSPL that exist as a result of alternative splicing events. Since both of these isoforms reduce the level of phosphorylated Rb protein when transfected into mammary carcinoma cells, CTDSPL functions primarily as a phosphatase. The gene encoding CTDSPL is deleted in 15% of major epithelial cancers, suggesting that CTDSPL plays a role in tumor suppression. Due to evidence showing that inactive small CTD phosphatases interfere with the Repressor Element 1-silencing transcription factor/Neuron-Restrictive silencer factor (REST/NRSF) complex, therefore promoting neuronal differentiation, it is suspected that CTDSPL may function as a transcription regulator that acts to silence neuronal genes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of CTDSPL of mouse and human origin by WB, IF and ELISA non cross-reactive with family members CTDSP1 or CTDSPL2 also reactive with additional species, including bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of CTDSPL of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of CTDSPL of human origin |
| Entrez Gene | 10217 |
|---|
| Application Notes | recommended for detection of CTDSPL of mouse and human origin by WB, IF and ELISA non cross-reactive with family members CTDSP1 or CTDSPL2 also reactive with additional species, including bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
