Application
Western blot analysis of FUSIP1 expression in non-transfected 293T: (A), mouse FUSIP1 transfected 293T: (B) and Hep G2 (C) whole cell lysates.Application
Western blot analysis of FUSIP1 expression in Jurkat whole cell lysate.Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human lung tissue showing nuclear staining.| Product Name | FUSIP1 Antibody (E-23) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | FUSIP1 (FUS interacting protein (serine/arginine-rich) 1), also known as NSSR, TASR (TLS-associated protein with Ser-Arg repeats), SRp38, TASR1, TASR2, FUSIP2, SFRS13 or SRrp40 (40 kDa SR-repressor protein), is a member of the Serine/Arginine (SR) family of splicing factors. Members of the SR family all contain one or more RNA recognition motifs (RRM) and an SR-rich domain. SR factors are not only essential for constitutive splicing but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. Expressed in a variety of tissues with low expression in kidney, liver and heart, FUSIP1 localizes to the cytoplasm and nuclear speckles. In its dephosphorylated form (occurring during M phase of the cell cycle), FUSIP1 functions as a potent general repressor of pre-mRNA splicing and can interact with U1 SnRNP 70. In its phosphorylated form, FUSIP1 interacts with Tra-2∫ and, together, they may cooperate in the regulation of splicing. Four isoforms exist for FUSIP1. In neurons, FUSIP1 isoforms may act to either positively or negatively regulate alternative splicing. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of FUSIP1 of mouse and human origin by WB, IP, IF, IHC(P) and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against FUSIP1 of human origin |
|---|---|
| Tissue Specificity | raised against FUSIP1 of human origin |
| Entrez Gene | 10772 |
|---|
Application
Western blot analysis of FUSIP1 expression in non-transfected 293T: (A), mouse FUSIP1 transfected 293T: (B) and Hep G2 (C) whole cell lysates.
Application
Western blot analysis of FUSIP1 expression in Jurkat whole cell lysate.
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human lung tissue showing nuclear staining.| Application Notes | recommended for detection of FUSIP1 of mouse and human origin by WB, IP, IF, IHC(P) and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
