Breast and kidney-expressed chemokine (BRAK) is a highly selective monocyte chemoattractant. The CXC chemokine BRAK, which is ubiquitously expressed in normal tissue extracts, is absent from many tumor cell lines in vitro. BRAK, also known as CXCL14, is involved in the generation of tissue macrophages by recruiting extravasated precursors to fibroblasts, which are known to secrete essential cytokines for macrophage development. The gene encoding BRAK is located on human chromosome 5q31.This gene belongs to the cytokine family which encodes secreted proteins involved in immunoregulatory and inflammatory processes. The BRAK protein is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines characterized by two cysteines separated by a single amino acid.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
recommended for detection of BRAK of mouse rat and human origin by WB IP and ELISA also reactive with additional species including canine
Tissue Specificity
recommended for detection of BRAK of mouse, rat and human origin by WB, IP and ELISA; also reactive with additional species, including canine