| Modification Notes |
The cationic amino acid transporter (CAT) family of proteins are part of a larger superfamily, the amino acid-polyamine-organocation (APC) superfamily. High-affinity cationic amino acid transporter-1 (CAT-1), also designated ecotropic retroviral leukemia receptor homolog, ATRC1 or REC1L, is a ubiquitously expressed integral membrane protein. In non-hepatic tissues, CAT-1 acts as a high-affinity, low capacity permease that is important in cationic amino acid transport. CAT-1 is also a potential ecotropic retroviral leukemia receptor. SLC7A1, the gene encoding for the CAT-1 protein, maps to chromosome 13q12-q14. |