| Product Name | SESN2 Antibody (H-62) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | SESN2, also known as sestrin 2, HI95, SES2 or SEST2, is a 480 amino acid protein that belongs to the sestrin family of PA26-related proteins. Expressed in a variety of tissues throughout the body, SESN2 is thought to be involved in the regulation of cell growth and survival and may play a role in mediating stress-induced cellular responses. SESN2 expression is upregulated following oxidative stress or DNA damage. This leads to cell toxicity and subsequent apoptosis, implying an essential role for SESN2 in the regulation of cell viability. Conversely, overexpression of SESN2 in breast cancer cells leads to protection from apoptosis, suggesting a possible role for SESN2 in tumor progression. SESN2 is, therefore, a crucial regulator of cell survival whose function varies depending on cellular conditions. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SESN2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 45-106 mapping near the N-terminus of SESN2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 45-106 mapping near the N-terminus of SESN2 of human origin |
| Entrez Gene | 83667 |
|---|
| Application Notes | recommended for detection of SESN2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
