| Product Name | rBAT Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Heterodimeric amino acid transporters mediate the transfer of amino acids between organs and between different cell types. The heavy chain subunit is a type II membrane protein with an intracellular amino terminus, a single transmembrane helix, and a large intracellular domain. The SLC3A1 gene encodes one of these heavy chains, rBAT, which dimerize with a light chain subunit (7 types have been identified) to facilitate reabsorption of dibasic amino acids and cystine in renal and intenstinal epithelial cells. Defects in this transport system causes cystinuria, a disease that manifests as the development of kidney stones. Mutations in SLC3A1 or the gene encoding the light chain subunit, SLC7A9, both cause cystinuria, the former classified as “Type I” and the latter as “non-type I”, however, the clinical presentation of the two is indistinguishable, expounding the importance of the functional complex, and not just one subunit, for normal amino acid transport. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of rBAT of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 111-410 mapping within an extracellular domain of rBAT of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 111-410 mapping within an extracellular domain of rBAT of human origin |
| Entrez Gene | 6519 |
|---|
| Application Notes | recommended for detection of rBAT of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
