Application
Western blot analysis of Orai3 expression in AML-193 (A) and A549 (B) whole cell lysates and human recombinant Orai3 fusion protein (C).| Product Name | Orai3 Antibody (H-51) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Orai3 (ORAI calcium release-activated calcium modulator 3), also known as TMEM142C (transmembrane protein 142C), is a 295 amino acid multi-pass membrane protein that belongs to the Orai family of proteins. Localizing to the plasma membrane, Orai3 plays an important role in store-operated calcium (SOC) entry, a process involving Ca(2+) influx and replenishment of Ca(2+) stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca(2+) mobilizing agents. CRAC channels are responsible for mediating calcium influx in T cells and play an important role in the immune response. Orai3, specifically, also acts as a regulator or component of the nuclear import of transcription factor NFAT. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Orai3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-51 mapping at the N-terminus of Orai3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-51 mapping at the N-terminus of Orai3 of human origin |
| Entrez Gene | 93129 |
|---|
Application
Western blot analysis of Orai3 expression in AML-193 (A) and A549 (B) whole cell lysates and human recombinant Orai3 fusion protein (C).| Application Notes | recommended for detection of Orai3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
