| Product Name | netrin G1 Antibody (H-55) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Netrin G1 and netrin G2, also referred to as laminet-1 and laminet-2, are membrane bound axon guidance molecules involved in synaptic formation and maintenance. They comprise a subgroup within the UNC-6/netrin family. Both genes have been associated with schizophrenia involving single nucleotide polymorphisms. They are both expressed in the brain but G1 is most predominantly expressed in the thalamus and G2 is most predominantly expressed in the cortex. These two proteins differ from classical netrins by their failure to bind netrin receptors, the presence of a glycosyl phosphatidylinositol membrane anchor, and the generation of multiple isoforms. Netrin G1 has at least nine isoforms, all of which are expressed in adult brain. Isoforms G1a, c, d, and e are also expressed in fetal brain. G1c and G1d are the most highly expressed netrin G1 isoforms. Netrin G1 is involved in NMDA receptor function and may play a role in Rett syndrome (RTT), atypical autism, epilepsy and mental retardation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of netrin G1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 175-229 mapping within an internal region of netrin G1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 175-229 mapping within an internal region of netrin G1 of human origin |
| Entrez Gene | 22854 |
|---|
| Application Notes | recommended for detection of netrin G1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
