| Product Name | Na+ CP type Vα Antibody (H-170) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Voltage-gated sodium channels drive the initial depolarization phase of the cardiac action potential and, therefore, critically determine conduction of excitation through the heart. The sodium channel gene SCN5A, which encodes the Na+ CP type Vå protein, possesses two fundamental properties, ion conduction and gating. The human SCN5A gene maps to chromosome 3q21-24. Deletions or loss-of-function mutations in SCN5A result in a wide range of arrhythmias, including bradycardia, atrioventricular conduction delay and ventricular fibrillation. Specifically, patients with Brugada syndrome have mutations in the SCN5A gene, which reduces the sodium current. Additionally, gain-of-function mutations are associated with long QT syndrome type III (LQT3), a cardiac disorder that causes sudden death from ventricular tachyarrhythmias, specifically torsade de pointes. The SCN5A gene is expressed in human atrial and ventricular cardiac muscle, but not in adult skeletal muscle, brain, myometrium, liver or spleen. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Na+ CP type V&alpha of mouse, rat and human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 971-1140 mapping to an internal region of Na+ CP type V&alpha of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 971-1140 mapping to an internal region of Na+ CP type Vα of human origin |
| Entrez Gene | 6331 |
|---|
| Application Notes | recommended for detection of Na+ CP type V&alpha of mouse, rat and human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
