| Modification Notes |
TSSC1 (tumor suppressing subtransferable candidate 1) is a 387 amino acid protein that contains five WD repeat domains—motifs that may be involved in protein-protein interactions. Expressed throughout the body, TSSC1 is composed of three exons and shares similarity with RbAp48 (a retinoblastoma binding protein) and the Drosophila protein Caf-1. The gene encoding TSSC1 is thought to be associated with a tumor-suppressing region that, if altered, can lead to lung, ovarian and breast cancer, rhabdomyosarcoma, Beckwith-Wiedemann syndrome, Wilms’ tumor, low birth weight and adrenocortical carcinoma. |