| Product Name | LDLRAD3 Antibody (N-16) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Members of the low-density lipoprotein receptor (LDLR) gene family mediate the endocytosis of extracellular ligands. LDLRAD3 (LDLR class A domain-containing protein 3) is a 345 amino acid single-pass type I membrane protein that contains three LDLR class A domains. The gene encoding LDLRAD3 maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of LDLRAD3 of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with LDLRAD1 or LDLRAD2 also reactive with additional species, including equine, canine, bovine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an N-terminal extracellular domain of LDLRAD3 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an N-terminal extracellular domain of LDLRAD3 of human origin |
| Entrez Gene | 143458 |
|---|
| Application Notes | recommended for detection of LDLRAD3 of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with LDLRAD1 or LDLRAD2 also reactive with additional species, including equine, canine, bovine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
