| Modification Notes |
The eukaryotic PDZ domain is a multifunctional protein-protein interacting motif that is found in a variety of proteins and is involved in both the clustering of signaling molecules and the organization of protein networks. LNX3 (ligand of Numb protein X 3), also known as PDZRN3 (PDZ domain containing ring finger 3) or SEMCAP3 (semaphorin cytoplasmic domain-associated protein 3), is a 1,066 amino acid protein that contains one TRAF-type zinc finger, one RING-type zinc finger and two PDZ domains. Expressed in a variety of tissues, LNX3 interacts with neuroligin 1 and ephrin-B2 and may exhibit tumor suppressive activity in ovarian serous papillary tumors. Multiple isoforms of LNX3 exist due to alternative splicing events. |