Application
Western blot analysis of METTL3 expression in Raji whole cell lysate.| Product Name | METTL3 Antibody (B-23) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | METTL3 (methyltransferase like 3), also known as M6A, IME4, Spo8 or MT-A70, is a 580 amino acid nuclear speckle protein belonging to the methyltransferase superfamily, which includes DNA methyltransferases (Dnmt), histone methyltransferases and catechol-O-methyl transferases, as well as many others. Members of this family have enzymatic activity that results in the transfer of a methyl group to and from DNA, RNA or amino acids. Widely expressed at low levels, it is suggested that METTL3 may be associated with nuclear pre-mRNA splicing components. Considered a N6-methyltransferase, METTL3 methylates adenosine residues of some mRNAs. N6-methyladenosine is present at internal sites of several mRNAs, which may play a role in the efficiency of mRNA splicing, transport or translation. The gene encoding METTL3 is located on human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Produced by alternative splicing events, two isoforms of METTL3 exists. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of METTL3 of mouse rat and human origin by WB IP and ELISA also reactive with additional species including canine |
|---|---|
| Tissue Specificity | recommended for detection of METTL3 of mouse, rat and human origin by WB, IP and ELISA; also reactive with additional species, including canine |
| Entrez Gene | 56339 |
|---|
Application
Western blot analysis of METTL3 expression in Raji whole cell lysate.| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
