| Product Name | ARHGAP8 Antibody (N-16) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the N-terminus of ARHGAP8 of human origin |
| Modification Notes | ARHGAP8 (Rho GTPase activating protein 8), also known as PP610 or BPGAP1, is a 464 amino acid protein that contains one Rho GAP domain and one CRAL-TRIO domain. Expressed at high levels in placenta and kidney, and at lower levels in testis, stomach, colon, small intestine and skeletal muscle, ARHGAP8 functions as a negative regulator of Rho-type GTPases, specifically catalyzing the conversion of the target GTPase to an inactive, GDP-bound state. Via its catalytic activity, ARHGAP8 is thought to play a role in signaling pathways and cytoskeletal changes throughout the cell. ARHGAP8 is overexpressed in colorectal and breast tumors, suggesting a role for ARHGAP8 in carcinogenesis. Human ARHGAP8 shares 80% homology with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of ARHGAP8 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of ARHGAP8 of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with family member ARHGAP28 also reactive with additional species, including equine, canine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of ARHGAP8 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of ARHGAP8 of human origin |
| Entrez Gene | 23779 |
|---|
| Application Notes | recommended for detection of ARHGAP8 of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with family member ARHGAP28 also reactive with additional species, including equine, canine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
