| Modification Notes |
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF33A (zinc finger protein 33A), also known as KOX2, KOX5, KOX31, NF11A, ZNF11, ZNF33, ZZAPK or ZNF11A, is a 810 amino acid nuclear protein belonging to the Krüppel C2H2-type zinc-finger protein family. Containing sixteen C2H2-type zinc fingers and a KRAB domain, ZNF33A may be involved in transcriptional regulation. ZNF33A is suggested to increase E2F expression and induce cyclin E/CDK2 activity. ZNF33A interacts with and is suppressed by MLTK. |