Application
Western blot analysis of serum carnosinase expression in mouse brain tissue extract.Application
Western blot analysis of serum carnosinase expression in rat cerebellum tissue extract.| Product Name | serum carnosinase Antibody (E-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of serum carnosinase of human origin |
| Modification Notes | Serum carnosinase, also known as CNDP1 (carnosine dipeptidase 1), CN1 or CPGL2, is a 507 amino acid protein that is secreted into central nervous system (CNS) tissue and is a member of the peptidase M20A family. Existing as a homodimer, serum carnosinase uses zinc as a cofactor to catalyze the hydrolysis of beta-Ala-I-His and Xaa-I-His dipeptides, including carnosine, thereby playing a role in glucose metabolism. Serum carnosinase functions as an optimal pH of 8.5 and contains a varying number of trinucleotide (CTG) repeats that control its enzymatic activity. Polymorphisms in the serum carnosinase gene are associated with homocarnosinosis, as well as with diabetic nephropathy in type 1 diabetes. The gene encoding serum carnosinase maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of serum carnosinase of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of serum carnosinase of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of serum carnosinase of human origin |
| Entrez Gene | 84735 |
|---|
Application
Western blot analysis of serum carnosinase expression in mouse brain tissue extract.
Application
Western blot analysis of serum carnosinase expression in rat cerebellum tissue extract.| Application Notes | recommended for detection of serum carnosinase of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
